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An Automated Online Positioning System and Simulation Environment for Multi-Electrodes in Extracellular Recordings
Zitatschlüssel Franke2010e
Autor Franke, F., Natora, M., Meier, P., Hagen, E., Pettersen, K.H., Linden, H., Einevoll, G., and Obermayer, K.
Buchtitel 32nd Annual International IEEE EMBS Conference 2010, Buenos Aires, Argentina
Seiten 593-597
Jahr 2010
ISBN 978-1-4244-4123-5
ISSN 1557-170X
DOI 10.1109/IEMBS.2010.5626631
Journal Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE
Monat November
Zusammenfassung Extracellular recordings are a key tool to record the activity of neurons in vivo. Especially in the case of experiments with behaving animals, however, the tedious procedure of electrode placement can take a considerable amount of expensive and restricted experimental time. Furthermore, due to tissue drifts and other sources of variability in the recording setup, the position of the electrodes with respect to the recorded neurons can change causing low recording quality. The contributions of this work are threefold. We introduce a quality measure for the recording position of the electrode which should be maximized during recordings and is especially suitable for the use of multi-electrodes. An automated positioning system based on this quality measure is proposed. The system is able to find favorable recording positions and adapts the electrode position smoothly to changes of the neuron positions. Finally, we evaluate the system using a new simulator for extracellular recordings based on realistically reconstructed 3D neurons.
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